Our Lab’s New Paper, Led by Postdoctoral Fellow Neeraj Soni, Unveiling a Novel Strategy for Single-Molecule Protein Analysis

In this work, we demonstrate that small oligonucleotides 🧬 can act as proxies for cysteine residues to ultimately reveal protein identity!
We further show how protein translocation speed can be regulated to enhance time resolution and how the delivery of single-file proteins is significantly improved using negatively charged oligonucleotides. Finally, we apply a machine learning approach to identify specific proteins within a mixture, highlighting the potential of this strategy for advancing protein fingerprinting and single-molecule analysis.

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