2018

 
Adv_Funct_Mater_2018_Var.jpg

A Solid‐State Hard Microfluidic–Nanopore Biosensor with Multilayer Fluidics and on‐Chip Bioassay/Purification Chamber.

Varongchayakul, N.; Hersey, J. S.; Squires, A. H.; Meller, A.; Grinstaff, M. W. A Solid‐State Hard Microfluidic–Nanopore Biosensor with Multilayer Fluidics and on‐Chip Bioassay/Purification Chamber. Adv. Funct. Mater. 2018, 1804182.

 
acsnano_wang-2018.png

Single-Molecule Discrimination of Labeled DNAs and Polypeptides Using Photoluminescent-Free TiO2 Nanopores

Wang, R.; Gilboa, T.; Song, J.; Huttner, D.; Grinstaff, M.W.; Meller, A. Single-Molecule Discrimination of Labeled DNAs and Polypeptides Using Photoluminescent-Free TiO2 Nanopores. ACS Nano, 2018, DOI: 10.1021/acsnano.8b07055

 
Sci Rep 2018 Gilboa.jpg

Optically-Monitored Nanopore Fabrication Using a Focused Laser Beam

Gilboa, T.; Zrehen, A.; Girsault, A.; Meller, A. Optically-Monitored Nanopore Fabrication Using a Focused Laser Beam. Sci Rep 2018, 8, 9765.

 
Chem. Soc. Rev. 2018 Varongchayakul.jpg

Single-molecule protein sensing in a nanopore: a tutorial

Varongchayakul, N.; Song, J.; Meller, A.; Grinstaff, M. W. Single-molecule protein sensing in a nanopore: a tutorial. Chem Soc Rev, 2018

 
Sci Rep 2018 Varongchayakul.jpg

Sensing Native Protein Solution Structures Using a Solid-State Nanopore: Unraveling the States of VEGF

Varongchayakul, N.; Huttner, D.; Grinstaff, M. W.; Meller, A.. Sensing Native Protein Solution Structures Using a Solid-State Nanopore: Unraveling the States of VEGF. Sci Rep, 2018, 8:1017, 1-9.


 

2017

 
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Single-Molecule DNA Unzipping Reveals Asymmetric Modulation of a Transcription Factor by Its Binding Site Sequence and Context.

Rudnizky, S., Khamis, H., Malik, O., Squires, A. H.; Meller A ., Melamed,. Kaplan, A. (2017) Single-Molecule DNA Unzipping Reveals Asymmetric Modulation of a Transcription Factor by Its Binding Site Sequence and Context. Nuc. Acid Res.

 
Nanoscale 2017 Zrehen.jpg

Real-time visualization and sub-diffraction limit localization of nanometer-scale pore formation by dielectric breakdown

Zrehen, A; Gilboa, T. and Meller, A. (2017) Real-time visualization and sub-diffraction limit localization of nanometer-scale pore formation by dielectric breakdown, Nanoscale, 9(42), 16437-16445. DOI: 10.1039/c7nr02629c

 
Adv_Mater_2017_Assad.jpg

Light-Enhancing Plasmonic-Nanopore Biosensor for Superior Single-Molecule Detection.

Assad, O. N.; Gilboa, T.; Spitzberg, J.; Juhasz, M.; Weinhold, E.; Meller, A. (2017) Light-Enhancing Plasmonic-Nanopore Biosensor for Superior Single-Molecule Detection. Adv. Mater., 1605442–1605449.

 
Single-molecule Enzymology2017.jpg

Single-Molecule Characterization of DNA-Protein Interactions Using Nanopore Biosensors

Review - Squires, A. H.; Gilboa, T.; Torfstein, C.; Varongchayakul, N.; Meller, A. Single-Molecule Characterization of DNA-Protein Interactions Using Nanopore Biosensors; Methods in Enzymol. Part B, 1-33.; 2017, Elsevier Inc., ; pp. 1–33.


 

2015-2016

 
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Single-Molecule DNA Methylation Quantification Using Electro-Optical Sensing in Solid-State Nanopores.

Gilboa, T.; Torfstein, C.; Juhasz, M.; Grunwald, A.; Ebenstein, Y.; Weinhold, E.; Meller, A. Single-Molecule DNA Methylation Quantification Using Electro-Optical Sensing in Solid-State Nanopores. ACS Nano, 2016, 10, 8861–8870. doi:10.1021/acsnano.6b04748

 
Anal Chem 2015 Hersey.jpg

Functionalized Nanofiber Meshes Enhance Immunosorbent Assays.

Hersey, J. S., Meller, A. & Grinstaff, M. W. Functionalized Nanofiber Meshes Enhance Immunosorbent Assays. Anal. Chem. acs.analchem.5b03386 (2015). doi:10.1021/acs.analchem.5b03386

 
PLoS ONE 2015 Squires.jpg

Genomic Pathogen Typing Using Solid-State Nanopores

Squires, A., Atas, E. and Meller, A. Genomic Pathogen Typing Using Solid-State Nanopores, PLoS ONE. 2015, 10, e0142944.

 
Biophysical Journal 2015 Nir.png

Direct Sensing and Discrimination among Ubiquitin and Ubiquitin Chains Using Solid-State Nanopores

Nir, I., Huttner, D. and Meller, A. Direct Sensing and Discrimination among Ubiquitin and Ubiquitin Chains Using Solid-State Nanopores, Biophys. J. 108(9), 2015, 2340-2349.

 
Sci Rep 2015 Squires.png

Nanopore sensing of individual transcription factors bound to DNA

Squires, A., Atas, E. and Meller, A. Nanopore sensing of individual transcription factors bound to DNA, Sci. Rep. 2015, 5, 1-11.

 
Nano Lett. 2014 Assad.png

Two Color DNA Barcode Detection in Photoluminescence Supressed Silicon Nitride Nanopores

Assad, O.N., Di Fiori, N., Squires, A.H. and Meller, A. Two Color DNA Barcode Detection in Photoluminescence Supressed Silicon Nitride Nanopores, Nano Letters, 2015, 15, 745-752. DOI: 10.1021/nl504459c

 
Analyst 2015 Gilboa.png

Optical sensing and analyte manipulation in solid- state nanopores

Review - Hitron, T. and Meller A. Optical sensing and analyte manipulation in solid- state nanopores. Analyst. 2015, DOI: 10.1039/c4an02388a


 

2014

 
ACS Nano 2014 Anderson.png

Probing Solid-State Nanopores with Light for the Detection of Unlabeled Analyte

Anderson, B.N., Assad, O.N., Gilboa,T., Squires, A.H. Bar, D. and Meller, A. Probing Solid-State Nanopores with Light for the Detection of Unlabeled Analyte, ACS Nano, 2014, 8(11), 11836-11845.

 
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Stationary nanoliter droplet array with a substrate of choice for single adherent/nonadherent cell incubation and analysis

Shemesh, J., Ben Arye, T., Avesar,J., Kang,J.H., Fine,A., SuperM., Meller, A., Ingber, D.E. and Levenberg S. Stationary nanoliter droplet array with a substrate of choice for single adherent/nonadherent cell incubation and analysis, Proc. Natl. Acad. Sci. USA, 2014, 111(31), 11293-11298.

 
Structure 2014 Sun.png

Single Moleculae Kinetics of the Eukaryotic Initiation Factor 4AI Upon RNA Unwinding

Sun, Y., Atas, E., Lindqvist, L .M., Sonenberg, N., Pelletier, J. and A. Meller, Single Moleculae Kinetics of the Eukaryotic Initiation Factor 4AI Upon RNA Unwinding, Structure, 2014, 22(7), 941-948.


 

2011-2013

 
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Optoelectronic control of surface charge and translocation dynamics in solid-state nanopores

Di Fiori, N. Squires, A. H, Bar, D., Gilboa, T. Moustakas, T.D. and A. Meller. Optoelectronic control of surface charge and translocation dynamics in solid-state nanopores, Nature Nanotechnology, 2013, 8, 946-951.

 
J. Am. Chem. Soc. 2013 Squires.png

A Nanopore–Nanofiber Mesh Biosensor To Control DNA Translocation

Squires, A. H., J. S. Hersey, M. W. Grinstaff, and A. Meller. A Nanopore–Nanofiber Mesh Biosensor To Control DNA Translocation . J. Am. Chem. Soc., 2013, 135(44), 16304-116307

 
ACS Nano 2013 Anderson.png

pH Tuning of DNA Translocation Time through Organically Functionalized Nanopores

Anderson BN, Muthukumar M, Meller A. pH Tuning of DNA Translocation Time through Organically Functionalized Nanopores. ACS Nano. 2012, 7(2): 1408-1414

 
Nanotechnology 2012 dela Torre.png

Fabrication and characterization of solid-state nanopore arrays for high-throughput DNA sequencing

Dela Torre R, Larkin J, Singer A, Meller A. Fabrication and characterization of solid-state nanopore arrays for high-throughput DNA sequencing. Nanotechnology. 2012, 23(38):385308. doi: 10.1088/0957-4484/23/38/385308. Epub 2012 Sep 5.

 
Nucleic Acids Res 2012 Sun.png

The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase

Sun Y, Atas E, Lindqvist L, Sonenberg N, Pelletier J, Meller A. The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase. Nucleic Acids Res. 2012, 40(13), 6199-207. doi: 10.1093/nar/gks278. Epub 2012 Mar 28.

 
Biophysical Journal 2012 Lin.png

Nanopore detachment kinetics of poly(A) binding proteins from RNA molecules reveals the critical role of C-terminus interactions

Lin J, Fabian M, Sonenberg N, Meller A. Nanopore detachment kinetics of poly(A) binding proteins from RNA molecules reveals the critical role of C-terminus interactions. Biophys J. 2012, 102(6), 1427-1434. doi: 10.1016/j.bpj.2012.02.025. Epub 2012 Mar 20.

 
Nano Lett. 2012 Singer.png

Electronic barcoding of a viral gene at the single-molecule level

Singer A, Rapireddy S, Ly DH, Meller A. Electronic barcoding of a viral gene at the single-molecule level. Nano Lett. 2012, 12(3):1722-1728. doi: 10.1021/nl300372a. Epub 2012 Feb 24.

 
Lab Chip 2011 Kim.png

Programmed trapping of individual bacteria using micrometre-size sieves

Kim, M.-C., Isenberg, B.C., Sutin, J., Meller, A., Wong, J.Y., and Klapperich, C.M. Programmed trapping of individual bacteria using micrometre-size sieves. Lab on a Chip 2011, 11, 1089-1095.

 
Biophysical Journal 2013 Squires.png

DNA Capture and Translocation through Nanoscale Pores - a Fine Balance of Electrophoresis and Electroosmosis

Review - Squires A.H. and Meller A. DNA Capture and Translocation through Nanoscale Pores - a Fine Balance of Electrophoresis and Electroosmosis, Biophysical J. New and Notable, 2013, 105, 543-544.

 

DNA sequencing by nanopore-induced photon emission

Review - Singer A, McNally B, Torre RD, Meller A. DNA sequencing by nanopore-induced photon emission. Methods Mol Biol. 2012, 870:99-114. doi: 10.1007/978-1-61779-773-6_6.

 
Electrophoresis 2012 Atas.png

DNA sequencing and bar-coding using solid-state nanopores

Review - Atas E, Singer A, Meller A. DNA sequencing and bar-coding using solid-state nanopores. Electrophoresis. 2012, 33(23):3437-47. doi: 10.1002/elps.201200266. Epub 2012 Oct 30.


 

2010

 
Phys Biol 2010 Livingstone.png

Mechanisms governing the control of mRNA translation

Livingstone, M., Atas, E., Meller, A., and Sonenberg, N. Mechanisms governing the control of mRNA translation. Phys Biol, 2010, 7, 021001.

 
J Phys Condens Matter 2010 Singer.png

Detection of urea-induced internal denaturation of dsDNA using solid-state nanopores

Singer, A., H. Kuhn, M. Frank-Kamenetskii, and A. Meller. Detection of urea-induced internal denaturation of dsDNA using solid-state nanopores  J. Phys. Cond-Mat., 2010, 22, 454111.

 
Nano Lett. 2010 Mcnally.png

Optical Recognition of Converted DNA Nucleotides for Single-Molecule DNA Sequencing Using Nanopore Arrays

McNally, B., A. Singer, Z. Yu, Y. Sun, Z. Weng, and A. Meller. Optical Recognition of Converted DNA Nucleotides for Single-Molecule DNA Sequencing Using Nanopore Arrays. Nano Letters, 2010, 10(6) 2237-44.

 
Biophysical Journal 2010 Di Fiori.png

The effect of dye-dye interactions on the spatial resolution of single-molecule FRET measurements in nucleic acids

Di Fiory, N. and A. Meller. The effect of dye-dye interactions on the spatial resolution of single-molecule FRET measurements in nucleic acids. Biophys. J., 2010, 98, 2265-72

 
Phys Rev Lett 2010 Lin.png

Helix-coil kinetics of individual polyadenylic acid molecules in a protein channel

Lin, J., Kolomeisky, A. and Meller, A. Helix-coil kinetics of individual polyadenylic acid molecules in a protein channel. Phys. Rev. Lett. 2010, 104, 158101-4

 
2010 Singer.png

Nanopore-based sequence-specific detection of duplex DNA for genomic profiling

Singer, A., Wanunu, M., Morrison, W., Kuhn, H., Frank-Kamenetskii, M., and Meller, A. Nanopore-based sequence-specific detection of duplex DNA for genomic profiling. Nano Letters. 2010, 10, 738-742.

 
Rev Sci Instrum 2010 Soni.png

Synchronous optical and electrical detection of bio-molecules traversing through solid-state nanopores

Soni, V. G., Singer, A., Yu, Z., Sun, Y., McNally, B. and Meller, A. Synchronous optical and electrical detection of bio-molecules traversing through solid-state nanopores. Rev. Sci. Instru. 2010, 81, 014301-014307. 

 
Nat Nanotechnol 2010 Wanunu.png

Electrostatic Focusing of Unlabeled DNA into Nanoscale Pores using a Salt Gradient

Wanunu, M., Morrison, W., Rabin, Y., Grosberg, A. Y. and Meller, A. Electrostatic Focusing of Unlabeled DNA into Nanoscale Pores using a Salt Gradient, Nature Nano. 2010, 5,160-165.

 
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Localized Joule heating produced by ion current focusing through micron-size holes.

Viasnoff, V., U. Bockelmann, A. Meller, H. Isambert, L. Laufer, and Y. Tsori. Localized Joule heating produced by ion current focusing through micron-size holes. Appl. Phys. Lett. 2010, 96, 163701-163703.

 

Nanopore-based Sensing of Individual Nucleic Acid Complexes

Review - Singer, A. and A. Meller. (2010). Nanopore-based Sensing of Individual Nucleic Acid Complexes. Israel Journal of Chemistry 49:323–331.

 
Methods in enzymology 2010 Dudko.png

Nanopore Force Spectroscopy tools for analyzing single biomolecular complexes

Review - Dudko, O., Mathé, J. and Meller A. (2010) Nanopore Force Spectroscopy tools for analyzing single biomolecular complexes, In Methods in Enzymology Ed. Walter, N.

 
 

Analyzing Individual Biomolecules Using Nanopores

Review - Wanunu, M. Soni, G. and A. Meller. Analyzing Individual Biomolecules Using Nanopores, in the “Handbook of Nanophysics” K.D. Sattler (Ed), 2010 Taylor & Francis Group.


2000-2009

2007-2009

  • Valencia-Burton, M. Shah, A. Sutin, J. Borogovac, A., McCullough, R. Cantor, C.R. Meller, A. and Broude, N.E. (2009) Spatiotemporal patterns and transcription kinetics of induced RNA in single bacterial cells,  Proc. Natl. Acad. Sci. U.S.A. 106, 16399-16404.

  • Wanunu, M. Sutin, J. and A. Meller (2009) DNA Profiling Using Solid-State Nanopores: Detection of DNA-Binding Molecules, Nano Letters, 9, 3498-3502.

  • Wanunu, M. Sutin, J. McNally, B. Chow, A. and A. Meller (2008) DNA Translocation Governed by Interactions with Solid State Nanopores, Biophys. J. 95, 4716-25.

  • McNally, B. Wanunu, M. and A. Meller (2008) Electro-mechanical unzipping of individual DNA molecules using synthetic sub-2 nm pores, Nano Letters8, 3418-22.

  • Wanunu, M. Chakrabarti, B. Mathé, J. Nelson, D. R. and A. Meller (2008) Orientation-dependent interactions of DNA with an a-Hemolysin Channel, Phys Rev. E, 77, 031904.

  • Soni G. and A. Meller (2007) Progress Towards ultrafast DNA sequencing using solid state nanopores. Clin. Chem3, 1996-01

  • Kim, M-J., B. McNally, K. Murata and A. Meller (2007) Characteristics of solid-state nanometer pores fabricated using transmission electron microscope (TEM) Nanotechnology, 18, 205302.

  • Dudko, O., J. Mathé, A. Szabo, A. Meller, and G. Hummer (2007) Extracting kinetics from single-molecule force spectroscopy: Nanopore unzipping of DNA hairpins, Biophys. J.92, 4188-4195.

  • Wanunu, M. and A. Meller (2007) Chemically Modified Solid-State 
    Nanopores. Nano Letters,  7, 1580-85, (also read  Research HighlightNature447, 14 (2007)

  • Hornblower, B., A. Coombs, R.D. Whitaker, A. Kolomeisky, Picone, S.J., A. Meller and M. Akeson (2007) Single-Molecule Analysis of DNA-Protein Complexes Using Nanopores. Nature Methods,  4, 315-317 DOI: 10.1038/nmeth1021.

  • Edel, J., J. Eid and A. Meller (2007) Accurate single molecule FRET efficiency determination for surface immobilized DNA using maximum likelihood calculated lifetimes. J. Phys. Chem B.111, DOI: 10.1021/jp066530k.


2000-2006

  • Kim, M-J., M. Wanunu, C.D. Bell and A. Meller (2006) Rapid Fabrication of Uniform Size Nanopores and Nanopore Arrays for Parallel DNA Analysis. Adv. Mater. 18, 3149-3153.

  • Jan Bonthuis, D., J. Zhang, B. Hornblower, J. Mathé, B.I. Shklovskii and A. Meller (2006) Self-Energy-Limited Ion Transport in Subnanometer Channels. Phys. Rev. Lett. 97, 128104.

  • Mathé, J., A. Arinstein, Rabin Y. and A. Meller (2006) Equilibrium and irreversible unzipping of DNA in a nanopore, Europhys. Lett. 73 (1), 128-134.

  • Viasnoff, V., A. Meller and H. Isambert (2006) DNA nanomechanical switches under folding kinetics control. Nano Letters6, 101-104.

  • Sabanayagam, C.R., J.S. Eid and A. Meller (2005) Long time scale blinking kinetics of cyanine fluorophores conjugated to DNA and its effect on Förster resonance energy transfer. J. Chem. Phys. 123, 224708.

  • Mathé, J., A. Aksimentiev, D.R. Nelson, K. Schulten and A. Meller (2005) Orientation discrimination of single-stranded DNA inside the alpha-hemolysin membrane channel. Proc. Natl. Acad. Sci. U.S.A. 102, 12377-12382.

  • Sabanayagam, C.R., J.S. Eid and A. Meller (2005) Using fluorescence resonance energy transfer to measure distances along individual DNA molecules: Corrections due to nonideal transfer. J. Chem. Phys. 122, 061103.

  • Mathé, J., H. Visram, V. Viasnoff, Y. Rabin and A. Meller (2004) Nanopore unzipping of individual DNA hairpin molecules. Biophys. J. 87, 3205-3212.

  • Sabanayagam, C.R., J.S. Eid and A. Meller (2004) High-throughput scanning confocal microscope for single molecule analysis. Appl. Phys. Lett. 84, 1216-1218.

  • Bates, M., M. Burns and A. Meller (2003) Dynamics of single DNA molecules actively controlled inside a membrane channel. Biophys. J. 84, 2366-2372.

  • Meller, A., L. Nivon and D. Branton (2001) Voltage-Driven DNA Translocations through a Nanopore. Phys. Rev. Lett. 86, 3435-3438.

  • Meller, A. and D. Branton (2002) Single molecule measurements of DNA transport through a nanopore. Electrophoresis 23, 2583-2591.

  • Meller, A., L. Nivon, E. Brandin, J. Golovchenko and D. Branton (2000) Rapid nanopore discrimination between single polynucleotide molecules. Proc. Natl. Acad. Sci. U.S.A. 97, 1079-1084.


Reviews

  • Review - Dudko, O. and Meller, A. (2009) Probing Biomolecular Interactions Using Nanopore Force Spectroscopy. In Encyclopedia of Analytical Chemistry, Meyers, R. A., Ed. John Wiley & Sons Ltd.

  • Review - Wanunu, M. G. Soni and A. Meller (2009) Single molecule studies of nucleic acids interactions using nanopores, In: Handbook of Single-Molecule Biophysics, Springer, in press

  • Review - Branton D. et. al. (2008) The potential and challenges of nanopore sequencing, Nature Biotechnology 26, 1146-53.

  • Review - Wanunu, M. and A. Meller (2008) Single Molecule Analysis of Nucleic Acids and DNA-protein Interactions using Nanopores, Laboratory Manual on Single Molecules, Eds. P. Selvin and T. Ha, Cold Spring Harbor Press.

  • Review - Lee, J.W. and A. Meller (2006). Rapid DNA Sequencing by Direct Nanoscale Reading of Nucleotide Bases on Individual DNA chains. In: Perspectives in Bioanalysis. K. Mitchelson (Ed.), Elsevier.

  • Review - Meller, A. (2003) Dynamics of polynucleotide transport through nanometre-scale pores. J. Phys.: Condens. Matter 15, R581-R607.

  • Review - Branton, D. and A. Meller (2002) Using nanopores to discriminate between single molecules of DNA. 177-185 In: Structure and Dynamics of Confined Polymers, Kluwer Academic Publishers.


1992-1999

1992-1999

  • Meller, A., J. Stavans, T. Gisler, and D.A. Weitz. (1999) Viscoelasticity of Depletion-Induced Gels in Emulsion-Polymer Systems. Langmuir 15:1918-1922.

  • Tlusty, T., A. Meller, and R. Bar-Ziv. (1998) Optical gradient forces of strongly localized fields. Phys. Rev. Lett. 81:1738-1741.

  • Meller, A., R. Bar-Ziv, T. Tlusty, E. Moses, J. Stavans and S.A. Safran. (1998). Localized dynamic light scattering: A new approach for dynamic measurements in optical microscopy. Biophys. J. 74:1541-1548.

  • Bar-Ziv, R., A. Meller, T. Tlusty, E. Moses, J. Stavans and S.A. Safran (1997). Localized Dynamic Light Scattering: Probing Single Particle Dynamics at the Nanoscale. Phys. Rev. Lett. 78:154-157.

  • Meller, A. and J. Stavans (1996). Stability of Emulsions with Nonadsorbing Polymers. Langmuir 12:301-304

  • Steiner, U., A. Meller, and J. Stavans (1995). Entropy Driven Phase Separation in Binary Emulsions. Phys. Rev. Lett. 74:4750-4753.

  • Meller, A. and J. Stavans. (1992). Glass transition and phase diagrams of strongly interacting binary colloidal mixtures. Phys. Rev. Lett. 68:3646-3649.