In our research, we introduced solid-state nanopore sensing using a compact microfluidic device for label-free quantification of SARS-CoV-2 RNA in clinical nasal swab samples. This research was conducted in Prof. Meller’s lab in collaboration with Dr. Ronit Almog and her staff in the epidemiology unit in the Rambam Medical center. We graded nasal swab samples from >15 subjects and found that the SARS-CoV-2 radiometric nanopore index correlates well with the reported RT-qPCR threshold cycle for positive classified samples. Remarkably, nanopore analysis also reports quantitative positive outcomes for clinical samples classified as negative by RT-qPCR, suggesting that the method may be used to diagnose COVID-19 in samples that may evade detection.
Our paper on SARS-CoV-2 sensing is out in Nanoscale journal.
