Our lab members represented us in SMPS3 conference in Delft, the Netherlands.
Dr. Yulia Marom, Dr. Navneet Verma Chandra, Neeraj, Liran, Shilo, Noam, and Prof. Meller presented our research in single molecule sequencing. The group presented five different posters, each one on a different topic.
Meller lab won the 2022 MOST Sweden-Israel award.
Prof. Meller is among the recipients of this year’s awards - The MOST Sweden-Israel award with his colleagues at the Royal Institute of Technology, to develop novel plasmonic nanopore sensors for clinical bio molecular markers.
Our lab had some renovations and it looks good!
In the last two weeks our lab had some renovations. Our lab members took a major part of the work. here are some pictures from the painting work.
Neeraj Soni's paper on ACS Nano journal
Single-File Translocation Dynamics of SDS-Denatured, Whole Proteins through Sub-5 nm Solid-State Nanopores
In this paper we characterize the voltage dependence translocation dynamics of a wide molecular weight range of denatured proteins (from 14 to 130 kDa) through sub-5 nm solid-state nanopores, using a SDS concentration below the critical micelle concentration. Our results suggest that proteins’ translocation dynamics are significantly slower than expected, presumably due to the smaller nanopore diameters used in our study and the role of the electroosmotic force opposing the translocation direction. This allows us to distinguish among the proteins of different molecular weights based on their dwell time and electrical charge deficit.
Prof. Meller won The Diane Sherman Prize for Medical Innovation for a Better World
Prof. Meller was awarded the 2021-2022 Academic Excellence Award :
The Diane Sherman Prize for Medical Innovation for a Better World.
Our paper on SARS-CoV-2 sensing is out in Nanoscale journal.
In our research, we introduced solid-state nanopore sensing using a compact microfluidic device for label-free quantification of SARS-CoV-2 RNA in clinical nasal swab samples. This research was conducted in Prof. Meller’s lab in collaboration with Dr. Ronit Almog and her staff in the epidemiology unit in the Rambam Medical center. We graded nasal swab samples from >15 subjects and found that the SARS-CoV-2 radiometric nanopore index correlates well with the reported RT-qPCR threshold cycle for positive classified samples. Remarkably, nanopore analysis also reports quantitative positive outcomes for clinical samples classified as negative by RT-qPCR, suggesting that the method may be used to diagnose COVID-19 in samples that may evade detection.