Lab Fun Day & Farewell
Yesterday, our lab team spent a wonderful day together in Haifa!
We joined a guided food tour in the lively Talpiot Market, tasted delicious dishes, and enjoyed learning about the local food culture. It was a great chance to relax, laugh, and spend time together outside the lab.
Later, we also said goodbye to Barak, Noam, and Malak, who are leaving the lab to start new adventures. We will really miss them and wish them all the best!
The day was full of smiles, good food, and great company. A perfect way to celebrate our amazing team!
Our Lab’s New Paper, Led by Postdoctoral Fellow Neeraj Soni, Unveiling a Novel Strategy for Single-Molecule Protein Analysis
In this work, we demonstrate that small oligonucleotides can act as proxies for cysteine residues to ultimately reveal protein identity!
We further show how protein translocation speed can be regulated to enhance time resolution and how the delivery of single-file proteins is significantly improved using negatively charged oligonucleotides. Finally, we apply a machine learning approach to identify specific proteins within a mixture, highlighting the potential of this strategy for advancing protein fingerprinting and single-molecule analysis.
Click here to read the article
Prof. Meller preseting the lab resent work at the CECAM workshop in Cagliari, italy
Prof. Amit Meller presented our lab’s recent work at the CECAM workshop, “Nanopores: From Basics to Applications.”
His talk focused on the use of solid-state nanopores for label-free identification of mitochondrial and cell-free DNA, as well as for protein fingerprinting.
Read more on CECAM website
Meller Lab Beach Gathering
Our team enjoyed a fun and relaxing day at the beach, filled with sunshine, good food, and great company. It was a perfect break from the lab and a chance to connect outside work. Thanks to everyone who joined!
Machine Learning Enables Rapid Detection of Unamplified mtDNA
We are excited to share groundbreaking research from out lab. Recently featured on the university's website, showcases an innovative approach for detecting mitochondrial DNA (mtDNA) without the need for amplification—a significant advancement in the fields of diagnostics and genomics.
Our innovative nanotechnology enables direct analysis of native mitochondrial DNA without amplification, dramatically improving both speed and accuracy. This breakthrough will accelerate research into mitochondrial dysfunctions linked to cancer and neurodegenerative diseases.
Malak Hijazi presented her research in faculty Seminar title : “ Studying fragmentation distribution of cell free DNA(cfDNA) in healthy and sick patients using solid-state nanopores”
In her seminar, Malak discussed the use of solid-state nanopores to detect cell-free DNA (cfDNA) length variations, a promising approach for non-invasive disease monitoring through liquid biopsy.
Solid-state nanopores enable direct, label-free, single-molecule analysis of cfDNA fragment sizes without the need for amplification, avoiding biases common in qPCR and NGS. By analyzing ion-current signatures during translocation, this method reveals detailed size distributions, enhancing diagnostic accuracy. It offers a fast, cost-effective tool with strong potential for early detection and point-of-care use in oncology.
Great work Malak!